Original Thermogenic Fat Burner (2024)

Original Thermogenic Fat Burner (2024)

What Is Lipodrene With Ephedra| How Does It Work| Is Lipodrene Banned| Lipodrene Ingredients| What Are The Benefits| Lipodrene Reviews| Alternatives To Lipodrene| Side Effects And Warnings| Disclaimer

If you’ve been a player in the bodybuilding game for a while, you’ve probably heard of Lipodrene with Ephedra, aka The Original Thermogenic Fat Burner. But, as you can imagine, what it was then isn’t the same now. That’s why we’re here to let you in on all the changes, the current status of Lipodrene, the reviews, and more!

Section Divider: What is Lipodrene

What is Lipodrene?

Lipodrene with ephedra, by Hi-Tech Pharmaceuticals, is a thermogenic weight loss product. But that’s not all Lipodrene has to offer! It contains a 3-way fat-burning system that is aimed to help you:

  1. Burn calories and fat
  2. Help control sugar cravings
  3. Suppress appetite

More than 15 years after it’s introduction, there have been over a billion tablets of Lipodrene sold. But, if you’ve tried Lipodrene in the past (prior to 2018), you may notice some changes. For more information on what’s different check out our blog on the Old Version vs The New.

Section Divider: How Does It Work

How Does It Work?

Before we get into the ingredient breakdown, let’s review what Lipodrene is meant to do. As we previously mentioned, it’s a thermogenic fat burner.

A thermogenic supplement is something (containing natural ingredients) formulated to increase your metabolism. This is done by helping your body burn more calories. When your body is burning calories, it generates more heat (1).

This process can help increase weight loss by increasing your body’s efficiency in burning calories (energy expenditure) through your metabolism. Increasing your metabolism ultimately means that your body will use the calories from the food you eat for energy instead of storing them as fat.  

Also, as we mentioned previously, Lipodrene has been a popular fat burner for years. So why wasn’t it available (as of October 2021)?

Section Divider: Is Lipodrene Banned?

Is Lipodrene Banned?

No! Lipodrene is not banned, though we can’t say whether its ingredients may cause issues for specific professions or customs/importation. We recommend contacting your employer or customs office for more information. 

Although Lipodrene with Ephedra isn’t banned, it has had it’s issues. Years ago (like prior to 2016), Lipodrene and many other fat burners contained a stimulant called DMAA, which has since not been allowed in dietary supplements in the US from the FDA. Lipodrene was then reformulated to contain DMHA, a DMAA-like stimulant. This ingredient also had it’s run-in with the FDA, but so far has held its ground as a dietary supplement.  

Fast forward to 2021, Lipodrene has had a rocky year. Early in April, one batch of Lipodrene had a lighter shade of yellow than users knew it to have. Luckily, we were assured by the VP at Hi-Tech Pharmaceuticals that the color variation had no effect on the batch’s efficacy. Unfortunately, this was followed by the importation delays for ingredients, which led to delays in production. However, as of 2024, there are no issues delaying production for Lipodrene!

This delay in production affected several fat burners, including:

  • Hydroxyelite
  • Lipodrene Elite, Hardcore, & Xtreme
  • Hellfire
  • Black Mamba
  • More.

With all that said, let’s dive into these ingredients!

Section Divider: Lipodrene Ingredient Breakdown

The Breakdown:

Like most fat burners, Lipodrene contains a proprietary blend. This means that instead of being given the milligrams of each ingredient in the blend, they disclose the total amount of milligrams for the blend. In total, Lipodrene contains 560 mg* of active ingredients. 

Lipodrene with ephedra (1)



This is a stimulant that interacts with your central nervous system or your CNS. This will help you feel more alert and give you a boost of energy. Caffeine is a good base stimulant that sets the foundation for the more exotic stimulants.

Including caffeine in a fat burner can also positively influence your metabolism (2). This can result in experiencing some appetite suppression in addition to energy.†

The Proprietary Blend:

The proprietary blend contains the bulk of ingredients. To help organize the label, we’ll break the ingredients into different categories. However, it is important to note that ingredients have multiple purposes. So, just because we sectioned an ingredient as an appetite suppressant doesn’t mean it doesn’t serve as a stimulant (or another purpose) as well.

Any stimulant, including caffeine, will have some degree of appetite suppression, thermogenesis, and focus properties. Yet, this is not always experienced by every individual. This is just because we are all different, and our bodies will react to products differently.†

Altogether, Lipodrene’s Prop Blend contains:

  • Ephedra Extract
  • 2-Aminoisoheptane HCl (DMHA)
  • Synephrine HCl
  • Theobromine
  • Green Tea Extract
  • Citrus Aurantium Extract
  • Hoodia Extract
  • Cassia Nomame Extract
  • Naringen
  • 6,7 Dihydroxybergamotin
  • 5-Methoxytryptamine HCl
  • L-5-Hydroxytryptophan
  • Yohimbine HCl

Heavy Stimulants:

A popular stimulant many years ago (prior to ~2002) was ephedrine. This herb promoted weight loss by means of increasing your metabolism. But this ingredient is no longer available in dietary supplements. Now supplements contain the alkaloid ephedra. Despite not being the exact same compound, ephedra exerts very similar effects. Including the effects on weight loss. (3)

To read more on what separates ephedra from ephedrine click here. Ephedra is most notably recognized for it’s effects on increasing energy and suppressing appetite.

The next heavy stimulant on the label is 2-Aminoispheptane (DMHA), which promotes energy, thermogenesis, focus, and even some mood-boosting properties. (4)

Following the phenylethylamine alkaloids is synephrine HCl. Synephrine HCl is an ingredient similar to ephedrine. This stimulant is also a strong appetite suppressant. Synephrine works by acting like natural adrenaline when ingested. This helps increase metabolism and boost energy without increasing blood pressure. (5) Citrus Aurantium Extract is rich in p-synephrine, an alkaloid with similar effects to Synephrine HCl. (6)

Other Stimulants:

The following ingredients contain stimulant properties but may not be as strong as the ones above. Of course, this is subjective, but we find (from customer feedback and data on scientific studies) that these ingredients are not as potent.

Our first ingredient in this category is theobromine. Theobromine, like caffeine, is a naturally occurring compound found in cacao plants and tea leaves. Since it is a stimulant, it provides energy and may help shed water weight. Like other stimulants, theobromine also has appetite-suppressing properties. (7)

Another stimulant found in tea leaves is Green tea extract. Green tea is rich in polyphenols, catechins, and caffeine. The combination of these compounds may increase weight loss, though more research is still needed to be certain. (8)

Our last stimulant is also the last ingredient on the label: Yohimbine HCl. This ingredient is usually a hit or miss for people. Some people love it and take it on it’s own and some try to stay away from it. However no matter where you stand on yohimbine one thing is clear, it is effective.†

Yohimbine is a mild stimulant and can help suppress appetite, but there’s more to its fat-burning properties. Yohimbe works in the body by blocking alpha-2 adrenergic receptors located in fat cells. Once yohimbine is bound to a fat cell, it “turns off” the alpha receptor, which allows the fat cells to mobilize and burn off. (9,10)

Appetite Suppression:

Now that we have discussed the stimulants in Lipodrene with ephedra, let’s discuss the other ingredients that set it apart.

As previously mentioned, all stimulants in this formula will have appetite-suppressing properties, but not all appetite-suppressing ingredients are stimulants. In Lipodrene with ephedra, this non-stim ingredient is Hoodia Extract.

Hoodia extract is from the Hoodia Gordon plant, which grows in the Kalahari Desert of southern Africa. Although hoodia extract is a popular appetite suppressant, more scientific data will be needed to conclude its effects. (11)

Mood Boosting:

A prominent feature of fat burners is the addition of mood-boosting ingredients. These ingredients generally provide a feeling of euphoria and aid focus.†

In Lipodrene’s case, this includes 5-Methoxytryptamine HCl and L-5-Hydroxytryptophan or 5-MT and 5-HTP. Both 5-MT and 5-HTP affect the neurotransmitter serotonin, which plays an important role in our overall well-being and happiness. (12,13)

5-MT, however, is a precursor to melatonin. Why include a sleep aid in a fat burner? In addition to its role in sleep, melatonin has anti-inflammatory and antioxidant properties. It also regulates blood pressure, immune function, and body temperature. Serotonin also acts as a precursor to melatonin; within the pineal gland, serotonin is acetylated and then methylated to yield melatonin. (14)

So what does this mean?

Combining 5-MT and 5-HTP may briefly increase serotonin levels and then yield to melatonin. (15) However, due to the stimulants in Lipodrene with ephedra, it is unlikely a user will experience the calming effects of melatonin.

What’s Left:

If you’ve been following along on the label, you may have noticed we skipped a couple of ingredients. These include Cassia Nomame, Naringen, and 6,7 dihydroxybergamottin.

Cassia nomame may prevent the stomach and intestines from absorbing dietary fat. This causes dietary fat to be excreted, which might promote weight loss in some people. (16)

Naringen helps burn fat by stimulating the production of a crucial fat-burning hormone, adiponectin. (17) When combined with synephrine, naringen may even increase energy expenditure. (18) Like naringin, 6,7 dihydroxybergamottin also comes from grapefruit. Therefore, it may also help with weight control through similar mechanisms. (19)

Section Divider: How to take Lipodrene

How to take Lipodrene?

Lipodrene, with Ephedra’s instructions, states to take 1-2 tablets in the morning and 1 tablet after lunch. They also warn people not to exceed 4 tablets daily.

Section Divider: Who Should Try Lipodrene with Ephedra

Who Should Try Lipodrene with Ephedra?

Lipodrene with ephedra may look intimidating from the number of ingredients on the label; however, it’s actually a great fat burner for first-time users and those with a higher tolerance to stimulants. With all supplements, you should assess your tolerance, and with Lipodrene, that is very easy to do. With a max of 4 tablets daily, you can play around with the dose timing for what works best for you.†

Section Divider: Lipodrene Benefits

 Lipodrene Benefits:

Like most fat burners, Lipodrene is stimulant-dominant. So, we expect the boost in energy and appetite suppression to be the most prominent effects of Lipodrene.† But as always, user experiences vary.

Lipodrene’s Benefits include:

  • Increased Energy†
  • Appetite Control†
  • Overall Improved Mood†
  • Weight Loss†

So, with that, let’s check out some reviews!

Section Divider: Lipodrene Reviews

Lipodrene Reviews:


Customer Review By Viktoriia: “was pleasantly surprised by the effect of these tablets. incredible amount of energy. Helps lose weight, controls appetite”

Customer Review By Chandler: “Energy, no appetite, and focus. Weight has gone down since taking.”

Customer Review By Jonathan: “I take one in the morning and I am good for the entire rest of the day. Completely eradicates appetite and leaves you wired. A little too wired to feel good, really, but worth it.”

Section Divider: Lipodrene Alternatives

Lipodrene Alternatives:

Looking for another consistent thermogenic? Checkout ECA Xtreme or Lean EFX

If you’re not sure if Lipodrene with ephedra is right for you, there are many Lipodrene versions you can try. Review our blog comparing them for more information on what’s different!

Section Divider: Wrapping Up

Wrapping Up!

And this marks the end of our post on Lipodrene with Ephedra. Thank you for reading! And as always, if there was something that wasn’t clear, another question you might have, or if you have another idea for a blog, Email Us!

Want to read how Lipodrene with Ephedra compares to other popular fat burners? Check out our other blogs below!

Section Divider: Side Effects and Warnings

Side Effects and Warnings:

Read the entire label before taking this product. Not for use by individuals under the age of 18 years. Do not use if you are pregnant or nursing. Individuals who consume caffeine with this product may experience serious adverse health effects. People who are sensitive to caffeine should consult a doctor before using. Do not consume synephrine or caffeine from other sources, including but not limited to:

  • Coffee
  • Tea
  • Soda
  • other dietary products
  • Medications containing caffeine or phenylephrine

Consult with your physician before use if you are taking medication, including but not limited to:

  • MAOI inhibitors
  • Aspirin
  • Antidepressants
  • Non-steroidal anti-inflammatory drugs
  • Products containing phenylephrine, ephedrine, pseudo-ephedrine, or other stimulants

Consult your physician before use if you have a medical condition, including but not limited to:

  • Heart, liver, kidney, or thyroid disease
  • Psychiatric or epileptic disorders
  • Difficulty urinating
  • Diabetes
  • High blood pressure
  • Cardiac arrhythmia
  • Recurrent headaches
  • Enlarged prostate
  • Glaucoma

Stop 2 weeks before surgery or if you experience:

  • Rapid heart beat
  • Dizziness
  • Severe headache
  • Shortness of breath

In case of accidental overdose, seek professional assistance or contact a poison control center immediately. Exceeding recommended serving may cause serious adverse health effects, including heart attack and stroke. Improper use of this product may be hazardous to a person’s health.

This product should not be used in place of or as a substitute for recommendations by your healthcare professional. No clinical study has been performed on Lipodrene®.

These statements are based upon the active ingredients:
  • Senegalia Berlandieri
  • Ephedra
  • Theobromine
  • Yohimbe
  • Citrus aurantium
  • Caffeine
  • Green tea
  • 5-HTP
  • 5-methoxytryptamine
  • Phenylethylamine

This product can raise your blood pressure and interfere with other drugs you may be taking. Talk to your doctor about this product.

This product contains ingredients that may be banned by some sports organizations and/or increase risk of false positive on a drug test. Please consult with your sport organization or physician before taking this product.

Section Divider: Disclaimer


†PLEASE NOTE: The intention of the information provided is for reference only. Furthermore, we are in no way providing medical advice or instruction. Instead, the information provided in this guide/blog utilizes anecdotal information and available studies/reviews. While our goal is to maintain and display accurate information, we can’t guarantee it represents the latest formulation of the product or information. Therefore, please visit the manufacturer’s website if you have any concerns. Also, the information above does not represent our views here at Same Day Supplements. Instead, these are the manufacturers’ and users’ views and information. The Food and Drug Administration has not evaluated these statements. Finally, these products aim not to diagnose, treat, cure, or prevent any disease or illness.

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